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ba0001pp29 | Arthritis and other joint diseases: translational and clinical | ECTS2013

A deletion mutation of the gene P58^IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

Gilbert Sophie , Nowell Mari , Bonnet Cleo , Ladiges Warren , Morton John , Duance Vic , Mason Debbie

Objective: The protein kinases, PKR, and PERK have been implicated in pro-inflammatory cytokine-mediated cartilage degradation in vitro and endoplasmic reticulum stress-induced arthritis respectively. The objective of this study was to establish whether loss of P58IPK, an inhibitor of PKR and PERK, results in a degenerative joint phenotype in vivo.Methods: Sections of knee joints from P58IPK-null and wild-type mice...

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Bone Abstracts

A deletion mutation of the gene P58^IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

BiosciAbstracts

Bone Abstracts

A deletion mutation of the gene P58IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice

BiosciAbstracts

A deletion mutation of the gene P58^IPK, the cellular inhibitor of PKR and PERK, results in a degenerative joint phenotype in mice